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Closely related to methadone, the synthetic compound levo -alpha -acetyl -methadol or LAAM (Brand name: ORLAMM), has an even longer duration of action (from 48 to 72 hours) than methadone, permitting a reduction in frequency of use.

In 1994, it was approved as a Schedule II treatment drug for narcotic addiction.

Both methadone and LAAM have high abuse potential. Their acceptability as narcotic treatment drugs is predicated on their ability to substitute for heroin, the long duration of action, and their mode of oral administration.

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