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The amygdala is a key brain region that helps regulate fear and anxiety, while the prefrontal cortex is critically involved in the control of fear.

The major conclusion from studies of fear conditioning is that the amygdala plays critical role in linking external stimuli to defense responses.

Damage to the amygdala (Bechara et al., 1995) or areas of temporal lobe including the amygdala (LaBar et al., 1995) produces de?cits in fear conditioning in humans

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