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Hydergine (ergoloid mesylates) is made from an organic source, the ergot fungus of rye plants. It was discovered by Dr. Albert Hoffman at Sandoz laboratories. As with the other nootropics, it appears to increase mental cognition, prevent damage to brain cells, improve protein synthesis, reduce accumulation of lipofuscin, increase oxygenation and increase the production of neurotransmitters. It has also been found to be a powerful antioxidant. One of it's most powerful abilities is to prevent damage to the brain from hypoxia, or too little oxygen. Therefore it has been very useful for stroke victims.

One presumed effect of Hydergine is that it appears to mimic a substance known as nerve growth factor (NGF). Thus it enhances the growth and branching of dendrites. This can be critical for creative thinking and memory.

Hydergine is available by doctor's prescription, though it can also be obtained through mail order. Known side effects with improper dosage are nausea, dizziness and headaches, but it is otherwise considered non-toxic.

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